Thermofluid Safe-by-Design for Particulate Product
The safe-by-design approach to fabricating nanostructures is an alignment between functionality and safety and has recently become a consideration in next-generation materials science. Even though metallic nanoparticles (NPs) have been intensively used in numerous applications over the past several decades because of their advantageous physicochemical properties, their applications are now limited because of unwanted hazardous effects on humans and the environment. Thus, surface modification or coordination of the NPs to tune their properties toward enhanced biological and environmental compatibility without substantial loss of their desirable functions has become an important research area.
Collaborators:
Dr. Wolfgang Parak (Associate Editor, ACS Nano), Professor, Institut für Nanostruktur- und Festkörperphysik (INF), Universität Hamburg
https://www.uni-marburg.de/fb13/forschungsgruppen/biophotonik
Dr. Flemming Cassee (Editor-in-Chief, Particle and Fibre Toxicology), Professor, Institute for Risk Assessment Sciences, Universiteit Utrecht
Aerosol Nanocomposite Direct Array
Aerosol single-pass assembly approach for fabrication of quasi-monodisperse hybrid droplets will be considered through international collaboration to develop a scalable manufacturing system of on-demand biofunctional nanocomposites. This collaboration from the global specialties in aerosol nanoparticle processing and droplet array technology would be the most suitable to enhance the monodispersity of hybrid droplets for assessing nanotoxicity and creating biofunctional nanoplatforms.
Collaborator:
Dr. Pavel Levkin, Group Leader, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology
http://www.levkingroup.com/index.php/team-members/205-jeong-hoon-byeon
Metal Nanoparticle Aerosol Thiolation/Chalcogenization
Aerosol transition nanometals are in situ incorporated with thiol-containing droplets under UV irradiation to form thiolated/chalcogenided metal nanoparticles in a single-pass configuration. For example, lead nanoparticles are thiolated to be Pb-SHOCR nanostructures, and they emit greenish luminescence at a cell nucleus region due to their ultrafine size and light relectance characteristics. The proposed reaction route would be suitable to conveniently fabricate quantum dots, lithium storage materials, nanocarriers, radioactive adsorption materials, etc.
Collaborator:
Dr. Kyungoh Doh, Associate Professor, College of Medicine, Yeungnam University
Graphene Oxide-Doxorubicin Nanoflake
A fully nanoscale graphene oxide (nGO) flake is prepared from a carbon encapsulated metal nanoparticle (CEMN), and it is incorporated with doxorubicin (Dox) for use in controlled release application. The Dox release kinetics is compared with microscale GO (mGO), and the result show that nGO supported Dox is more suitable for controlled release applications because of enhanced electrostatic attraction and capillary forces between the nGO and DOx from larger surface area.
Collaborator:
Dr. Kyungoh Doh, Associate Professor, College of Medicine, Yeungnam University
Graphene Oxide Based Multimodal Nanoplatform
A near-infrared (NIR)-induced chemothermal doxorubicin (DOX) release for anticancer activity was demonstrated using chitosan/polyethylene glycol (cPEG) incorporated fully lateral nanodimensional graphene oxide (nGO)@DOX flakes (i.e., nGO@DOX-cPEG) from a single-pass gas-phase self-assembly.
Collaborator:
Dr. Jong Oh Kim, Associate Professor, College of Pharmacy, Yeungnam University
Rapid Bioaerosol Monitoring
Size-classified aerosol particles are directly deposited on the surface of swabs for adenosine triphosphate analyses that generates relative luminescences, thus correlating with coloy forming units for rapid measurements of bioaerosols. A novel sampler is designed and prepared as a swab insertable device not only for more efficient and rapid bioaerosol detections but also for pratical and realizalbe applications.
Collaborator:
Dr. Jungho Hwang, Professor, School of Mechanical Engineering, Yonsei University
Aerosol Nanoparticle Toxicity Assessment
We describe an in situ approach to coat simulated inhalable aerosol nanoparticles (welding fume, Phip) by merging them with fluorescent agent or biocompatible component. Inorganic or hard nanoparticles as the simulated nanoparticles floating air flow were directly mixed with fluoresceinisothiocyanate-polyethyleneglycol (PEG)-amine or dopamine-PEG in co-flow configuration to coat the surface of the nanoparticles that could give traceability or biocompatibility. This in situ incorporation may hold promise to trace or inactivate deposition of a wide range of engineered and incidental inhalable aerosol nanoparticles.
Collaborator:
Dr. Kyungoh Doh, Associate Professor, College of Medicine, Yeungnam University
High Frequency Spark Ablation
Conductive nanoparticles are prepared using an AC high frequency (20-50 kHz) spark ablation to enhance mass production rate. In situ electrostatic particle charging is also employed to prevent unwanted agglomerations between the primary particles due to repulsive forces. Also, the gap distance between spark electrodes is automatically controlled through a moving stage system. This work will be applied to manufacture highly uniform ultrafine metallic nanoparticles for a broad range of nanotechnological applications.
Collaborator:
Dr. Jae Hong Park, Assistant Professor, School of Health Science, Purdue University